The causes — an evidence-graded map

Name: Depression exposure × evidence matrix
Creator: Depression Research

Every hypothesised cause we could find, rated on a five-point evidence scale and tagged risk or protective. Click a row for mechanism, key finding and caveats. Association is not causation — most exposure links are observational; the firmest evidence comes from genetics (Mendelian randomization) and trials.

Factor	Domain	Dir.	Evidence	Key finding

Scale: Causal Robust Moderate Emerging Contested · Download this data →